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Case Western University: Targeted Self-Management for Epilepsy and
ntal Illness (TIME)

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  • Martha Sajatovic, MD (Principal Investigator)
  • Samden Lhatoo (Co-Investigator)
  • Adam Perzynski (Co-Investigator)
  • Satya Sahoo (Co-Investigator)
  • Curtis Tatsuoka (Co-Investigator)
  • Guo-Qiang Zhang (Co-Investigator)
  • Elisabeth Welter, MS, MA (Study Coordinator)

Project identifier:
SIP 12-057 : Managing Epilepsy Well (MEW) Collaborating Center for Epilepsy Self-management Intervention Research

Start date: 9/30/2012TIME LOgo

Epilepsy affects approximately 2 million Americans and is associated with substantial disability, reduced quality of life, heavy stigma burden, and premature mortality due to disease-related and psychosocial factors such as Sudden Unexpected Death in Epilepsy (SUDEP) and suicide. This project targets a historically hard-to-reach group of individuals with epilepsy (the seriously and persistently mentally ill) and will refine an intervention adapted for use in people with epilepsy and SMI (E-SMI), with the intent to improve both neurological and mental health outcomes. The experimental intervention (Targeted Self-Management for Epilepsy and Mental Illness/TIME) is a person-centered, holistic approach that takes advantage of existing strengths in patients, families and community health entities. TIME is a practical and generalizable intervention suitable for implementation in specialty, primary care or community settings, and has the potential to reduce the unacceptably high morbidity and mortality seen in individuals challenged with E-SMI.

This project is important because it addresses epilepsy and serious mental illness concurrently. It has been reported that anywhere between 20-70% of people with epilepsy meet criteria for a psychiatric illness at some point (Vuilleumier 1998, Tucker 1998) and that risk of psychosis in people with epilepsy is 6-12 times that of the general population (Torta 1999).

Dr. Joseph Sirven, Professor of Neurology at Mayo Clinic Arizona and Editor-in-Chief of, interviews Martha Sajatovic, MD, Director, Neurological Outcomes Center, University Hospitals Case Medical Center about the Managing Epilepsy Well TIME Intervention.

Listen to the Podca
The Case Western Reserve University (CWRU) research team plans to engage a number of community mental health clinics and agencies including Recovery Resources and MHS (Mental Health Services).

This research project fits well within the MEW Network's mission of helping individuals with epilepsy maximize health outcomes and quality of life.


Vuilleumier P, Jallon P. [Epilepsy and psychiatric disorders: epidemiological data]. Rev Neurol (Paris). May 1998;154(4):305-17.
View PubMed Abstract
Tucker GJ. Seizure disorders presenting with psychiatric symptomatology. Psychiatr Clin North Am. Sep 1998;21(3):625-35, vi.
doi: 10.1016/S0193-953X(05)70027-7
View PubMed Abstract
Torta R, Keller R. Behavioral, psychotic, and anxiety disorders in epilepsy: etiology, clinical features, and therapeutic implications. Epilepsia. 1999;40 Suppl 10:S2-20.
doi: 10.1111/j.1528-1157.1999.tb00883.x
View PubMed Abstract

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